I think rather than just going into different brands and spouting my opinion on who sells the best AMPK activator supplement. I would rather educate you on what I consider to be the 5 best individual compounds for activating AMPK and talk about their benefits and effects individually.
If you want me to also review different brands of AMPK activators please comment on which ones you are interested in. I get quite a few reaching out and I don’t want to be that guy that is selling product. I do actually take Luz AMPK Activator (not an affiliate link) but if you have any other you think is great I am always open to new options.
Strongest AMPK Activator Ingredients
Berberine I consider to be the essential AMPK activator. It is a bit expensive which I suspect is why a lot of budget companies make ones that dont have this ingredient but I would personally suggest that you take this ingredient alone before you take a AMPK activator that doesn’t have it. It is the basis for a lot of pharmaceutical research because it works.
Activation Method: Reduction of PP2C expression
Effect: Improved insulin sensitivity and cell glucose uptake
Resveratrol is another one that you could take alone just for the health benefits but if you have a supplement with a few different ones you can eliminate the need to take 15 different pills. If your goal is weight loss I would say this is probably your first stop and most important ingredient as well as for longevity.
Activation Method: Unkown
Effect: Overall adipocyte (fat cell) decrease
Alpha Lipoic Acid
I think as a stack ALA is awesome. Where all these other ingredients get their effect through chemical process this one works directly on your metabolism. So if berbarine activated you 60% this will come from a completely different angle insuring maximum AMPK activation.
Activation Method: Mimics calorie surplus
Effect: Fasted effect/appetite suppression
Another great ingredient Gynostemma is able to increase your body’s access to stored calories allowing you to function on a higher level mentally while still cutting weight. So again if your looking at AMPK for weight loss this is a key ingredient.
Activation Method: Thr172 phosphorylation by LKB1
Effect: Improved glucose (sugar) and lipid (fat) metabolism
I can’t finish up this article without talking about Quercetin, its a great supplement and I wouldn’t ever say don’t take it but personally, When I am looking at this and berberine I think berberine wins out. If you are also looking for an antiviral or anti-inflammatory though you would probably do well finding a supplement with this rather than Berberine or both.
Activation Method: Reduction of PP2C expression
Effect: Improved insulin sensitivity
I hope I have given a little better insight into the different methods of AMPK activation and some of the strongest AMPK Activators. I hope that this will help you pick a supplement for yourself and be educated in your decision. I again personally take Luz AMPK Activator (again not an affiliate link) But that’s just the one that makes sense to me you might be happier with something simple like LCR.
If my focus is losing (fat) weight in a morbidly obese person, what is the most effective meal plan and exercise regiment to gain the most weight loss benefits. What are the side effect if not taken correctly?
If you take to much in a fasted state you can get blood sugar crashes.
Yes could you comment on life extensions Ampk activator?
Life Extensions AMPK Metabolic Activator is by far the best selling supplement and is very inexpensive. It used to just be Gynostemma and cloves but recently they changed the formula to include Hespiridan as well. I haven’t tried it since they changed it but before it was pretty mediocre.
I like your article but I would really like to know what brand to purchase???
I take Luz AMPK Activator which you can find on amazon.
Does the luz work well?
I don’t really want to comment on the efficacy of a specific brand. It is the one I take.
Thank you for your very succinct information about ampk. I found myself listening to the infomercial of Dr McClain and noticed at the beginning of the video that when they announced he was a doctor in Los Angeles they actually showed a segment of Rodeo Drive in Beverly Hills so right away that was a clue to me about cost! So I listen to for about 15 minutes got a little education about fat, and then started to do my research and found you. I don’t know anything about you but I liked what you had to say. I would love to hear your reply to me, and about who you are and what it is that you do and why you have this website. I’m a newbie so this inquiring mind wants to know! Thank you.
Is it safe to take this supplement if you are a 70-year-old female with digestive issues? Is there one that is better for seniors?
If your looking for an AMPK activator and have digestive challenges I would definitely try taking resveratrol or a low dose (250mg twice daily) of just berberine straight not a mix. Do one at a time and see if there are any side effects for you. A lot of these nutraceutical extracts have a real effect and can cause side effects like a gassy stomach if you get too high of a dosage for your digestive system too quickly.